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Article

Divergent and convergent evolution after a common-source outbreak of hepatitis C virus.

The Journal of experimental medicine - 6 Jun 2005

Ray Stuart C, Fanning Liam, Wang Xiao-Hong, Netski Dale M, Kenny-Walsh Elizabeth, Thomas David L

Abstract excerpt

The genomic sequences of viruses that are highly mutable and cause chronic infection tend to diverge over time. We report that these changes represent both immune-driven selection and, in the absence of immune pressure, reversion toward an ancestral consensus. Sequence changes in hepatitis C virus (HCV) structural and nonstructural genes were studied in a cohort of women accidentally infected with HCV in a rare...

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Identifiers

PMID: 15939791
DOI: 10.1084/jem.20050122
PMCID: PMC2213258

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Source receipt: pubmed, retrieved 7 Sept 2026.

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