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Article

Viral evolution explains the associations among hepatitis C virus genotype, clinical outcomes, and human genetic variation.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Dec 2013

Rose Rebecca, Markov Peter V, Lam Tommy T, Pybus Oliver G

Abstract excerpt

Specific human polymorphisms, most commonly found in Central Africa, can predict the success of drug treatment against the hepatitis C virus (HCV), a significant and globally-distributed human pathogen. However, this association is only found for a subset of HCV genotypes. Despite receiving considerable attention in the medical and virological literature, no evolutionary explanation for this curious pattern has...

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Identifiers

PMID: 24140473
DOI: 10.1016/j.meegid.2013.09.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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