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Article

BR-squared: a practical solution to the winner's curse in genome-wide scans.

Human genetics - 1 May 2011

Sun Lei, Dimitromanolakis Apostolos, Faye Laura L, Paterson Andrew D, Waggott Daryl, Bull Shelley B

Abstract excerpt

The detrimental effects of the winner's curse, including overestimation of the genetic effects of associated variants and underestimation of sufficient sample sizes for replication studies are well-recognized in genome-wide association studies (GWAS). These effects can be expected to worsen as the field moves from GWAS into whole genome sequencing. To date, few studies have reported statistical adjustments to the...

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Identifiers

PMID: 21246217
DOI: 10.1007/s00439-011-0948-2
PMCID: PMC3074069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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