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Article

Shrinkage estimation for robust and efficient screening of single-SNP association from case-control genome-wide association studies.

Genetic epidemiology - 1 Dec 2009

Luo Sheng, Mukherjee Bhramar, Chen Jinbo, Chatterjee Nilanjan

Abstract excerpt

Population-based case-control design has become one of the most popular approaches for conducting genome-wide association scans for rare diseases like cancer. In this article, we propose a novel method for improving the power of the widely used single-single-nucleotide polymorphism (SNP) two-degrees-of-freedom (2 d.f.) association test for case-control studies by exploiting the common assumption of Hardy-Weinberg...

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Identifiers

PMID: 19434716
DOI: 10.1002/gepi.20428
PMCID: PMC3103068

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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