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Article

Resampling to Address the Winner's Curse in Genetic Association Analysis of Time to Event.

Genetic epidemiology - 1 Nov 2015

Poirier Julia G, Faye Laura L, Dimitromanolakis Apostolos, Paterson Andrew D, Sun Lei, Bull Shelley B

Abstract excerpt

The "winner's curse" is a subtle and difficult problem in interpretation of genetic association, in which association estimates from large-scale gene detection studies are larger in magnitude than those from subsequent replication studies. This is practically important because use of a biased estimate from the original study will yield an underestimate of sample size requirements for replication, leaving the...

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PMID: 26411674
DOI: 10.1002/gepi.21920
PMCID: PMC4609263

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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