Article
Dynamic histone acetylation is critical for cotranscriptional spliceosome assembly and spliceosomal rearrangements.
Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 2011
Gunderson Felizza Q, Merkhofer Evan C, Johnson Tracy L
Abstract excerpt
Assembly of the spliceosome onto pre-mRNA is a dynamic process involving the ordered exchange of snRNPs to form the catalytically active spliceosome. These ordered rearrangements have recently been shown to occur cotranscriptionally, while the RNA polymerase is still actively engaged with the chromatin template. We previously demonstrated that the histone acetyltransferase Gcn5 is required for U2 snRNP...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.