Article
Functional antagonism between Sas3 and Gcn5 acetyltransferases and ISWI chromatin remodelers.
PLoS genetics - 1 Jan 2012
Lafon Anne, Petty Emily, Pillus Lorraine
Abstract excerpt
Chromatin-modifying enzymes and ATP-dependent remodeling complexes have been intensely studied individually, yet how these activities are coordinated to ensure essential cell functions such as transcription, replication, and repair of damage is not well understood. In this study, we show that the critical loss of Sas3 and Gcn5 acetyltransferases in yeast can be functionally rescued by inactivation of ISWI...
Topics
- Acetylation
- Adenosine Triphosphatases
- Chromatin Assembly and Disassembly
- Chromosomal Proteins, Non-Histone
- DNA-Binding Proteins
- Enzyme Activation
- Gene Expression Regulation, Fungal
- Histone Acetyltransferases
- Histones
- Mutation