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Article

Pre-mRNA splicing is a determinant of histone H3K36 methylation.

Proceedings of the National Academy of Sciences of the United States of America - 16 Aug 2011

Kim Soojin, Kim Hyunmin, Fong Nova, Erickson Benjamin, Bentley David L

Abstract excerpt

A chromatin code appears to mark introns and exons with distinct patterns of nucleosome enrichment and histone methylation. We investigated whether a causal relationship exists between splicing and chromatin modification by asking whether splice-site mutations affect the methylation of histone H3K36. Deletions of the 3' splice site in intron 2 or in both introns 1 and 2 of an integrated β-globin reporter gene...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 21807997
DOI: 10.1073/pnas.1109475108
PMCID: PMC3158196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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