Article
Pre-mRNA splicing is a determinant of histone H3K36 methylation.
Proceedings of the National Academy of Sciences of the United States of America - 16 Aug 2011
Kim Soojin, Kim Hyunmin, Fong Nova, Erickson Benjamin, Bentley David L
Abstract excerpt
A chromatin code appears to mark introns and exons with distinct patterns of nucleosome enrichment and histone methylation. We investigated whether a causal relationship exists between splicing and chromatin modification by asking whether splice-site mutations affect the methylation of histone H3K36. Deletions of the 3' splice site in intron 2 or in both introns 1 and 2 of an integrated β-globin reporter gene...
Topics
- Cell Line
- Histones
- Humans
- Methylation
- Mutation
- Protein Processing, Post-Translational
- RNA Precursors
- RNA Splice Sites
- RNA Splicing
- RNA, Messenger
- Ribonucleoproteins, Small Nuclear