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Article

Roles of TrkC Signaling in the Regulation of Tumorigenicity and Metastasis of Cancer

8 Jan 2020

Abstract excerpt

Tropomyosin receptor kinase (Trk) C contributes to the clinicopathology of a variety of human cancers, and new chimeric oncoproteins containing the tyrosine kinase domain of TrkC occur after fusion to the partner genes. Overexpression of TrkC and TrkC fusion proteins was observed in patients with a variety of cancers, including mesenchymal, hematopoietic, and those of epithelial cell lineage. Both microRNAs...

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PMID: 31936239
DOI: 10.3390/cancers12010147

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