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Article

Critical Role for TrkB Kinase Function in Anoikis Suppression, Tumorigenesis, and Metastasis

1 Jul 2007

Abstract excerpt

Anoikis, or cell death induced by cell detachment, provides protection against the metastatic spread of tumor cells. We have previously shown that the neurotrophic receptor tyrosine kinase TrkB suppresses anoikis in rat intestinal epithelial cells and renders them highly tumorigenic and metastatic. Because TrkB is overexpressed in several aggressive human cancers, first attempts are being made to target TrkB in...

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PMID: 17616679
DOI: 10.1158/0008-5472.can-07-0121

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