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Article

Characterization of the hyperphagic response to dietary fat in the MC4R knockout mouse.

Endocrinology - 1 Mar 2011

Srisai Dollada, Gillum Matthew P, Panaro Brandon L, Zhang Xian-Man, Kotchabhakdi Naiphinich, Shulman Gerald I, Ellacott Kate L J, Cone Roger D

Abstract excerpt

Defective melanocortin signaling causes hyperphagic obesity in humans and the melanocortin-4 receptor knockout mouse (MC4R(-/-)). The human disease most commonly presents, however, as haploinsufficiency of the MC4R. This study validates the MC4R(+/-) mouse as a model of the human disease in that, like the MC4R(-/-), the MC4R(+/-) mouse also exhibits a sustained hyperphagic response to dietary fat. Furthermore,...

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Identifiers

PMID: 21239438
DOI: 10.1210/en.2010-0716
PMCID: PMC3040060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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