Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene.

doi:10.1038/2647

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Article

Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene.

Nature medicine - 1 Oct 1998

Nonogaki K, Strack A M, Dallman M F, Tecott L H

Abstract excerpt

Brain serotonin and leptin signaling contribute substantially to the regulation of feeding and energy expenditure. Here we show that young adult mice with a targeted mutation of the serotonin 5-HT2C receptor gene consume more food despite normal responses to exogenous leptin administration. Chron...

Topics

Animals
Blood Glucose
Body Weight
Causality
Diabetes Mellitus, Type 2
Dietary Fats
Eating
Homeostasis
Hyperphagia
Insulin
Insulin Resistance
Leptin
Male
Mice
Mice, Mutant Strains
Mutation
Obesity
Proteins

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