Article

A Genetic Variant of Fatty Acid Amide Hydrolase (FAAH) Exacerbates Hormone-Mediated Orexigenic Feeding in Mice

2022-08-11

Abstract excerpt

Fatty acid amide hydrolase (FAAH) degrades the endocannabinoid anandamide. A polymorphism in FAAH (FAAH C385A) reduces FAAH expression, increases anandamide levels, and increases the risk of obesity. Nevertheless, some studies have found no association between FAAH C385A and obesity. We investigated whether the environmental context governs the impact of FAAH C385A on metabolic outcomes. Using a C385A knock-in mo...

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Literature Corpus work: 91c9abfb-6d0f-50ec-9ba1-6e9ec9040a8f
DOI: 10.1101/2022.08.09.503403

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