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Article

Altered hepatic lipid metabolism in mice lacking both the melanocortin type 4 receptor and low density lipoprotein receptor.

PloS one - 1 Jan 2017

Lede Vera, Meusel Andrej, Garten Antje, Popkova Yulia, Penke Melanie, Franke Christin, Ricken Albert, Schulz Angela, Kiess Wieland, Huster Daniel, Schöneberg Torsten, Schiller Jürgen

Abstract excerpt

Obesity is often associated with dyslipidemia and hepatosteatosis. A number of animal models of non-alcoholic fatty liver disease (NAFLD) are established but they significantly differ in the molecular and biochemical changes depending on the genetic modification and diet used. Mice deficient for melanocortin type 4 receptor (Mc4rmut) develop hyperphagia, obesity, and subsequently NAFLD already under regular chow...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28207798
DOI: 10.1371/journal.pone.0172000
PMCID: PMC5313158

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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