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Article

α-Conotoxin PeIA[S9H,V10A,E14N] potently and selectively blocks α6β2β3 versus α6β4 nicotinic acetylcholine receptors.

Molecular pharmacology - 1 Nov 2012

Hone Arik J, Scadden Mick'l, Gajewiak Joanna, Christensen Sean, Lindstrom Jon, McIntosh J Michael

Abstract excerpt

Nicotinic acetylcholine receptors (nAChRs) containing α6 and β2 subunits modulate dopamine release in the basal ganglia and are therapeutically relevant targets for treatment of neurological and psychiatric disorders including Parkinson's disease and nicotine dependence. However, the expression profile of β2 and β4 subunits overlap in a variety of tissues including locus ceruleus, retina, hippocampus, dorsal root...

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PMID: 22914547
DOI: 10.1124/mol.112.080853
PMCID: PMC3477225

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