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Article

An Accessory Agonist Binding Site Promotes Activation of α4β2* Nicotinic Acetylcholine Receptors.

The Journal of biological chemistry - 29 May 2015

Wang Jingyi, Kuryatov Alexander, Sriram Aarati, Jin Zhuang, Kamenecka Theodore M, Kenny Paul J, Lindstrom Jon

Abstract excerpt

Neuronal nicotinic acetylcholine receptors containing α4, β2, and sometimes other subunits (α4β2* nAChRs) regulate addictive and other behavioral effects of nicotine. These nAChRs exist in several stoichiometries, typically with two high affinity acetylcholine (ACh) binding sites at the interface of α4 and β2 subunits and a fifth accessory subunit. A third low affinity ACh binding site is formed when this...

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Identifiers

PMID: 25869137
DOI: 10.1074/jbc.M115.646786
PMCID: PMC4447965

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