Article
Biophysical and pharmacological characterization of α6-containing nicotinic acetylcholine receptors expressed in HEK293 cells.
Brain research - 13 Jan 2014
Rasmussen Andreas H, Strøbæk Dorte, Dyhring Tino, Jensen Marianne L, Peters Dan, Grunnet Morten, Timmermann Daniel B, Ahring Philip K
Abstract excerpt
Nicotinic acetylcholine receptors (nAChR's) containing the α6 subunit (α6) are putative drug targets of relevance to Parkinson's disease and nicotine addiction. However, heterologous expression of α6 receptors has proven challenging which has stifled drug discovery efforts. Here, we investigate potential new avenues for achieving functional α6 receptor expression. Combinations of chimeric and mutated α6, β2 and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.