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Article

Defining the putative inhibitory site for a selective negative allosteric modulator of human α4β2 neuronal nicotinic receptors.

ACS chemical neuroscience - 19 Sept 2012

Henderson Brandon J, González-Cestari Tatiana F, Yi Bitna, Pavlovicz Ryan E, Boyd R Thomas, Li Chenglong, Bergmeier Stephen C, McKay Dennis B

Abstract excerpt

Neuronal nicotinic receptors (nAChRs) have been implicated in several diseases and disorders such as autism spectrum disorders, Alzheimer's disease, Parkinson's disease, epilepsy, and nicotine addiction. To understand the role of nAChRs in these conditions, it would be beneficial to have selective molecules that target specific nAChRs in vitro and in vivo. Our laboratory has previously identified a novel...

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Identifiers

PMID: 23019495
DOI: 10.1021/cn300035f
PMCID: PMC3447398

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