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A West Nile virus mutant with increased resistance to acid-induced inactivation

12 Jan 2011

Abstract excerpt

West Nile virus (WNV) is a mosquito-borne flavivirus responsible for epidemics of febrile illness, meningitis, encephalitis and flaccid paralysis. WNV gains entry into host cells through endocytosis. The acid pH inside endosomes triggers rapid conformational rearrangements of the flavivirus envelope (E) glycoprotein that result in fusion of the endosomal membrane with the virion envelope. Conformational...

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PMID: 21228127
DOI: 10.1099/vir.0.027185-0

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