Article
Chemical Evolution of Rhinovirus Identifies Capsid-Destabilizing Mutations Driving Low-pH-Independent Genome Uncoating.
Journal of virology - 26 Jan 2022
Murer Luca, Petkidis Anthony, Vallet Thomas, Vignuzzi Marco, Greber Urs F
Abstract excerpt
Rhinoviruses (RVs) cause recurrent infections of the nasal and pulmonary tracts, life-threatening conditions in chronic respiratory illness patients, predisposition of children to asthmatic exacerbation, and large economic cost. RVs are difficult to treat. They rapidly evolve resistance and are genetically diverse. Here, we provide insight into RV drug resistance mechanisms against chemical compounds neutralizing...
Topics
- Antiviral Agents
- Capsid
- Capsid Proteins
- Drug Resistance, Viral
- Endosomes
- HeLa Cells
- Humans
- Hydrogen-Ion Concentration
- Intercellular Adhesion Molecule-1
- Mutation
- Protein Conformation
- Rhinovirus
- Virion
- Virus Internalization
- Virus Uncoating