Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of a single amino acid substitution of VP3 H142D for increased acid resistance of foot-and-mouth disease virus serotype A.

Virus genes - 1 Apr 2016

Biswal Jitendra K, Das Biswajit, Sharma Gaurav K, Khulape Sagar A, Pattnaik Bramhadev

Abstract excerpt

Foot-and-mouth disease virus (FMDV) particles lose infectivity due to their dissociation into pentamers at pH value below 6.5. After the uptake of FMDV by receptor-mediated endocytosis, the acid-dependent dissociation process is required for the release of FMDV genome inside endosomes. Nevertheless, dissociation of FMDV particles in mildly acidic conditions renders the inactivated FMD vaccine less effective. To...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acids
Share to Antigens, Viral
Share to Endosomes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Foot-and-Mouth Disease

Share to Foot-and-Mouth Disease Virus

Share to Genetic Fitness

Share to Serogroup

Share to Virus Activation

Source

Identifiers

PMID: 26873406
DOI: 10.1007/s11262-016-1294-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of a single amino acid substitution of VP3 H142D for increased acid resistance of foot-and-mouth disease virus serotype A.PMID 26873406Read ↗

Single amino acid substitution of VP1 N17D or VP2 H145Y confers acid-resistant phenotype of type Asia1 foot-and-mouth disease virus.Semantic proximity Read ↗

A single amino acid substitution in the capsid of foot-and-mouth disease virus can increase acid lability and confer resistance to acid-dependent uncoating inhibition.Semantic proximity Read ↗

Engineering viable foot-and-mouth disease viruses with increased acid stability facilitate the development of improved vaccines.Semantic proximity Read ↗

Adaptive value of foot-and-mouth disease virus capsid substitutions with opposite effects on particle acid stability.Semantic proximity Read ↗

An increase in acid resistance of foot-and-mouth disease virus capsid is mediated by a tyrosine replacement of the VP2 histidine previously associated with VP0 cleavage.Semantic proximity Read ↗

Targeted Modification of the Foot-And-Mouth Disease Virus Genome for Quick Cell Culture AdaptationSemantic proximity Read ↗

A Heat-Induced Mutation on VP1 of Foot-and-Mouth Disease Virus Serotype O Enhanced Capsid Stability and Immunogenicity.Semantic proximity Read ↗

Equine Rhinitis A Virus Mutants with Altered Acid Resistance Unveil a Key Role of VP3 and Intrasubunit Interactions in the Control of the pH Stability of the Aphthovirus Capsid.Semantic proximity Read ↗

Mutation in the VP2 gene of P1-2A capsid protein increases the thermostability of virus-like particles of foot-and-mouth disease virus serotype O.Semantic proximity Read ↗

SAT2 Foot-and-Mouth Disease Virus Structurally Modified for Increased Thermostability.Semantic proximity Read ↗

Analysis of Amino Acid Mutations of the Foot-and-Mouth Disease Virus Serotype O Using both Heparan Sulfate and JMJD6 Receptors.Semantic proximity Read ↗

A Temperature-Dependent Translation Defect Caused by Internal Ribosome Entry Site Mutation Attenuates Foot-and-Mouth Disease Virus: Implications for Rational Vaccine Design.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.