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Article

Single amino acid substitution of VP1 N17D or VP2 H145Y confers acid-resistant phenotype of type Asia1 foot-and-mouth disease virus.

Virologica Sinica - 1 Apr 2014

Wang Haiwei, Song Shanshan, Zeng Jianxiong, Zhou Guohui, Yang Decheng, Liang Te, Yu Li

Abstract excerpt

Infection by foot-and-mouth disease virus (FMDV) is triggered by the acidic pH in endosomes after virus uptake by receptor-mediated endocytosis. However, dissociation of the FMDV 146S particle in mildly acidic conditions renders inactivated foot-and-mouth disease (FMD) vaccines much less effective. Type Asia1 FMDV mutants with increased resistance to acid inactivation were selected to study the molecular basis of...

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Identifiers

PMID: 24752763
DOI: 10.1007/s12250-014-3426-x
PMCID: PMC8206435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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