Adaptive value of foot-and-mouth disease virus capsid substitutions with opposite effects on particle acid stability.

doi:10.1038/s41598-021-02757-3

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Article

Adaptive value of foot-and-mouth disease virus capsid substitutions with opposite effects on particle acid stability.

Scientific reports - 6 Dec 2021

Caridi Flavia, Cañas-Arranz Rodrigo, Vázquez-Calvo Ángela, de León Patricia, Calderón Katherine I, Domingo Esteban, Sobrino Francisco, Martín-Acebes Miguel A

Abstract excerpt

Foot-and-mouth disease virus (FMDV) is a picornavirus that exhibits an extremely acid sensitive capsid. This acid lability is directly related to its mechanism of uncoating triggered by acidification inside cellular endosomes. Using a collection of FMDV mutants we have systematically analyzed the relationship between acid stability and the requirement for acidic endosomes using ammonium chloride (NH4Cl), an...

Topics

Amino Acid Substitution
Animals
Capsid Proteins
Cell Line
Cricetinae
Endosomes
Foot-and-Mouth Disease
Foot-and-Mouth Disease Virus
Mutation

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Identifiers

PMID: 34873184
DOI: 10.1038/s41598-021-02757-3
PMCID: PMC8648728

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