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Article

Immune complexes containing scleroderma-specific autoantibodies induce a profibrotic and proinflammatory phenotype in skin fibroblasts.

Arthritis research & therapy - 29 Aug 2018

Raschi Elena, Chighizola Cecilia Beatrice, Cesana Laura, Privitera Daniela, Ingegnoli Francesca, Mastaglio Claudio, Meroni Pier Luigi, Borghi Maria Orietta

Abstract excerpt

BACKGROUND: In systemic sclerosis (SSc), autoantibodies provide the most accurate tool to predict the disease subset and pattern of organ involvement. Scleroderma autoantibodies target nucleic acids or DNA/RNA-binding proteins, thus SSc immune complexes (ICs) can embed nucleic acids. Our working hypothesis envisaged that ICs containing scleroderma-specific autoantibodies might elicit proinflammatory and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30157947
DOI: 10.1186/s13075-018-1689-6
PMCID: PMC6116570

Genes

NHS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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