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Article

Decreased interleukin-20 expression in scleroderma skin contributes to cutaneous fibrosis.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Jun 2014

Kudo Hideo, Jinnin Masatoshi, Asano Yoshihide, Trojanowska Maria, Nakayama Wakana, Inoue Kuniko, Honda Noritoshi, Kajihara Ikko, Makino Katsunari, Fukushima Satoshi, Ihn Hironobu

Abstract excerpt

OBJECTIVE: To clarify the role of interleukin-20 (IL-20) in the regulatory mechanism of extracellular matrix expression and to determine the contribution of IL-20 to the phenotype of systemic sclerosis (SSc). METHODS: Protein and messenger RNA (mRNA) levels of collagen, Fli-1, IL-20, and IL-20 receptor (IL-20R) were analyzed using polymerase chain reaction (PCR) array, immunoblotting, immunohistochemical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24470401
DOI: 10.1002/art.38380
PMCID: PMC4123870

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