Article
Aβ40(L17A/F19A) mutant diminishes the aggregation and neurotoxicity of Aβ40.
Biochemical and biophysical research communications - 4 Feb 2011
Chen Yi-Ru, Huang Hsien-bin, Lo Chi-Jen, Wang Chih-Ching, Su Chia-Li, Liu Hsin-Tzu, Shiao Ming-Shi, Lin Ta-Hsien, Chen Yi-Chen
Abstract excerpt
Aggregated β-amyloid peptides (Aβ) are neurotoxic and responsible for neuronal death both in vitro and in vivo. From the structural point of view, Aβ self-aggregation involves a conformational change in the peptide. Here, we investigated the relationship between conformational changes and amino acid residues of Aβ(40). Urea unfolding in combination with NMR spectroscopy was applied to probe the stabilization of...
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