Molecular insights into the effect L17A/F19A double mutation on the structure and dynamics of Aβ40 : A molecular dynamics simulation study.

Abstract excerpt

The aggregation of amyloid-β (Aβ) peptide has been associated with the pathogenesis of Alzheimer disease. The recent studies highlighted that L17A/F19A double mutation increases the structural stability of Aβ40 and diminish Aβ40 aggregation. However, the underlying effect of L17A/F19A double mutation on the Aβ40 structure and dynamics remain elusive. In this regard, the influence of L17A/F19A double mutation on...

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