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Article

Peptide backbone modifications of amyloid β (1-40) impact fibrillation behavior and neuronal toxicity.

Scientific reports - 9 Dec 2021

Schwarze Benedikt, Korn Alexander, Höfling Corinna, Zeitschel Ulrike, Krueger Martin, Roßner Steffen, Huster Daniel

Abstract excerpt

Fibril formation of amyloid β (Aβ) peptides is one of the key molecular events connected to Alzheimer's disease. The pathway of formation and mechanism of action of Aβ aggregates in biological systems is still object of very active research. To this end, systematic modifications of the Phe19-Leu34 hydrophobic contact, which has been reported in almost all structural studies of Aβ40 fibrils, helps understanding Aβ...

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Identifiers

PMID: 34887476
DOI: 10.1038/s41598-021-03091-4
PMCID: PMC8660793

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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