Article
Probing the Influence of Single-Site Mutations in the Central Cross-β Region of Amyloid β (1-40) Peptides.
Biomolecules - 9 Dec 2021
Fritzsch Jacob, Korn Alexander, Surendran Dayana, Krueger Martin, Scheidt Holger A, Mote Kaustubh R, Madhu Perunthiruthy K, Maiti Sudipta, Huster Daniel
Abstract excerpt
Amyloid β (Aβ) is a peptide known to form amyloid fibrils in the brain of patients suffering from Alzheimer's disease. A complete mechanistic understanding how Aβ peptides form neurotoxic assemblies and how they kill neurons has not yet been achieved. Previous analysis of various Aβ40 mutants could reveal the significant importance of the hydrophobic contact between the residues Phe19 and Leu34 for cell toxicity....
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