Article
Effect of alanine replacement of l17 and f19 on the aggregation and neurotoxicity of arctic-type aβ40.
PloS one - 1 Jan 2013
Chen Yi-Ru, Huang Hsien-bin, Lo Chi-Jen, Wang Chih-Ching, Ho Li-Kang, Liu Hsin-Tzu, Shiao Ming-Shi, Lin Ta-Hsien, Chen Yi-Cheng
Abstract excerpt
Alzheimer's disease is the most common form of neurodegenerative disease. Beta-amyloid peptides (Aβ) are responsible for neuronal death both in vitro and in vivo. Previously, L17 and F19 residues were identified as playing key roles in the stabilization of the Aβ40 conformation and in the reduction of its neurotoxicity. In this study, the effects of L17A/F19A mutations on the neurotoxicity of Aβ genetic mutant...
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