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Article

L17A/F19A Substitutions Augment the α-Helicity of β-Amyloid Peptide Discordant Segment.

PloS one - 1 Jan 2016

Liang Chu-Ting, Huang Hsien-Bin, Wang Chih-Ching, Chen Yi-Ru, Chang Chi-Fon, Shiao Ming-Shi, Chen Yi-Cheng, Lin Ta-Hsien

Abstract excerpt

β-amyloid peptide (Aβ) aggregation has been thought to be associated with the pathogenesis of Alzheimer's disease. Recently, we showed that L17A/F19A substitutions may increase the structural stability of wild-type and Arctic-type Aβ40 and decrease the rates of structural conversion and fibril formation. However, the underlying mechanism for the increase of structural stability as a result of the alanine...

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PMID: 27104649
DOI: 10.1371/journal.pone.0154327
PMCID: PMC4841593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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