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Article

In silico study on the effect of F19T mutation on amyloid-beta peptide (10-35).

Frontiers in bioscience : a journal and virtual library - 1 May 2008

Han Wei, Xiong Hao, Wu Yun-Dong

Abstract excerpt

The wild type (WT) amyloid-beta (10-35) peptide, Abeta (10-35), and its F19T mutant have been studied by molecular dynamics simulations at 340 K in explicit water solvent each for over 3.4 ms. The WT peptide has a strong preference to form an E22-K28 loop (44% of total conformations) and a reasonable stability for a strand-loop-strand (SLS, L17-M35) (9%). The F19T mutant has a significantly lower population of...

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Amyloid beta-Peptides
Drug Stability
Magnetic Resonance Spectroscopy
Molecular Conformation
Peptide Fragments

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PMID: 18508489
DOI: 10.2741/2983

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