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Article

Altered cholesterol ester cycle in skin fibroblasts from patients with Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2009

Pani Alessandra, Dessì Sandra, Diaz Giacomo, La Colla Paolo, Abete Claudia, Mulas Claudia, Angius Fabrizio, Cannas Maria D, Orru Christina D, Cocco Pier Luigi, Mandas Antonella, Putzu Paolo, Laurenzana Anna, Cellai Cristina, Costanza Antonio Mitidieri, Bavazzano Antonio, Mocali Alessandra, Paoletti Francesco

Abstract excerpt

Intracellular cholesterol metabolism was reported to modulate amyloid-beta (Abeta) generation in Alzheimer's disease (AD). Results presented herein demonstrated that, like brain cells, cultured skin fibroblasts from AD patients contained more cholesterol esters than fibroblasts from healthy subje...

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Identifiers

PMID: 19749436
DOI: 10.3233/JAD-2009-1193

Genes

BACE1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19749436-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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