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Article

Hepatitis B virus X protein stimulates IL-6 expression in hepatocytes via a MyD88-dependent pathway.

Journal of hepatology - 1 Jan 2011

Xiang Wen-Qing, Feng Wen-Feng, Ke Wei, Sun Zhen, Chen Zhi, Liu Wei

Abstract excerpt

BACKGROUND & AIMS: Hepatitis B virus (HBV) X protein (HBx) has been implicated in HBV-associated carcinogenesis by activating signal transduction pathways and influencing gene transcription in liver cells. We aimed to investigate the underlying mechanisms for HBx-induced production of interleukin-6 (IL-6), one of the major inflammatory mediators that stimulate hepatocellular carcinoma development. METHODS: HBx...

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Identifiers

PMID: 20937539
DOI: 10.1016/j.jhep.2010.08.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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