Article
Alternative splicing enriched cDNA libraries identify breast cancer-associated transcripts.
BMC genomics - 22 Dec 2010
Ferreira Elisa N, Rangel Maria C R, Galante Pedro F, de Souza Jorge E, Molina Gustavo C, de Souza Sandro J, Carraro Dirce M
Abstract excerpt
BACKGROUND: Alternative splicing (AS) is a central mechanism in the generation of genomic complexity and is a major contributor to transcriptome and proteome diversity. Alterations of the splicing process can lead to deregulation of crucial cellular processes and have been associated with a large spectrum of human diseases. Cancer-associated transcripts are potential molecular markers and may contribute to the...
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