Article
Nonrandom variations in human cancer ESTs indicate that mRNA heterogeneity increases during carcinogenesis.
Proceedings of the National Academy of Sciences of the United States of America - 1 May 2007
Brulliard Marie, Lorphelin Dalia, Collignon Olivier, Lorphelin Walter, Thouvenot Benoit, Gothié Emmanuel, Jacquenet Sandrine, Ogier Virginie, Roitel Olivier, Monnez Jean-Marie, Vallois Pierre, Yen Frances T, Poch Olivier, Guenneugues Marc, Karcher Gilles, Oudet Pierre, Bihain Bernard E
Abstract excerpt
Virtually all cancer biological attributes are heterogeneous. Because of this, it is currently difficult to reconcile results of cancer transcriptome and proteome experiments. It is also established that cancer somatic mutations arise at rates higher than suspected, but yet are insufficient to explain all cancer cell heterogeneity. We have analyzed sequence variations of 17 abundantly expressed genes in a large...
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