Article
Development of a novel splice array platform and its application in the identification of alternative splice variants in lung cancer.
BMC genomics - 3 Jun 2010
Pio Ruben, Blanco David, Pajares Maria Jose, Aibar Elena, Durany Olga, Ezponda Teresa, Agorreta Jackeline, Gomez-Roman Javier, Anton Miguel Angel, Rubio Angel, Lozano Maria D, López-Picazo Jose M, Subirada Francesc, Maes Tamara, Montuenga Luis M
Abstract excerpt
BACKGROUND: Microarrays strategies, which allow for the characterization of thousands of alternative splice forms in a single test, can be applied to identify differential alternative splicing events. In this study, a novel splice array approach was developed, including the design of a high-density oligonucleotide array, a labeling procedure, and an algorithm to identify splice events. RESULTS: The array...
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