Article
[PPARGC1A gene Thr394Thr G/A polymorphism and its association with type 2 diabetes mellitus and insulin resistance in a Chinese population].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Oct 2010
Song Jie, Liu Yuan-yuan, Long Yang, Tian Hao-ming, Liu Rui, Li Xiu-jun, Chen Tao, Zhang Xiang-xun, Yu Hong-ling, Ren Yan
Abstract excerpt
OBJECTIVE: To examine the association of the Thr394Thr polymorphism of PPARGC1A gene with type 2 diabetes (T2DM), insulin resistance (IR) and other metabolic disorders in a Chinese population. METHODS: Three hundred and seven subjects including 151 T2DM patients and 156 normal glucose tolerant controls (NC) were enrolled in this study. The Thr394Thr G/A polymorphism was genotyped using polymerase chain...
Topics
- Aged
- Asian People
- Case-Control Studies
- Diabetes Mellitus, Type 2
- Heat-Shock Proteins
- Humans
- Insulin Resistance
- Male
- Middle Aged
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
- Polymorphism, Single Nucleotide
- Transcription Factors