Article
Human Rho guanine nucleotide exchange factor 11 gene is associated with schizophrenia in a Japanese population.
Human psychopharmacology - 1 Nov 2014
Mizuki Yutaka, Takaki Manabu, Okahisa Yuko, Sakamoto Shinji, Kodama Masafumi, Ujike Hiroshi, Uchitomi Yosuke
Abstract excerpt
OBJECTIVE: The human Rho guanine nucleotide exchange factor 11 (ARHGEF11) gene is one of the candidate genes for type 2 diabetes mellitus (T2DM). ARHGEF11 is mapped to chromosome 1q21, which has susceptible risk loci for T2DM and schizophrenia. We hypothesized that ARHGEF11 contributes to the pathogenesis of schizophrenia. METHOD: We selected eight single nucleotide polymorphisms of ARHGEF11 that had significant...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
