Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene expression profiling reveals new aspects of PIK3CA mutation in ERalpha-positive breast cancer: major implication of the Wnt signaling pathway.

PloS one - 30 Dec 2010

Cizkova Magdalena, Cizeron-Clairac Géraldine, Vacher Sophie, Susini Aurélie, Andrieu Catherine, Lidereau Rosette, Bièche Ivan

Abstract excerpt

BACKGROUND: The PI3K/AKT pathway plays a pivotal role in breast cancer development and maintenance. PIK3CA, encoding the PI3K catalytic subunit, is the oncogene exhibiting a high frequency of gain-of-function mutations leading to PI3K/AKT pathway activation in breast cancer. PIK3CA mutations have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalysis
Share to Catalytic Domain
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Estrogen Receptor alpha

Share to Gene Expression Regulation, Neoplastic

Share to Oligonucleotide Array Sequence Analysis

Share to Phosphatidylinositol 3-Kinases

Share to Wnt Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 21209903
DOI: 10.1371/journal.pone.0015647
PMCID: PMC3012715

Genes

MSX2
LIMCH1
LTF
NRIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21209903-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene expression profiling reveals new aspects of PIK3CA mutation in ERalpha-positive breast cancer: major implication of the Wnt signaling pathway.PMID 21209903Read ↗

Molecular Insights of Pathways Resulting from Two Common PIK3CA Mutations in Breast Cancer.Semantic proximity Read ↗

The Effect and Treatment of PIK3CA Mutations in Breast Cancer: Current Understanding and Future DirectionsSemantic proximity Read ↗

LRG1 mRNA expression in breast cancer associates with PIK3CA genotype and with aromatase inhibitor therapy outcome.Semantic proximity Read ↗

PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer.Semantic proximity Read ↗

The mutational profiles and corresponding therapeutic implications of PI3K mutations in cancer.Semantic proximity Read ↗

PI3K mutations in breast cancer: prognostic and therapeutic implicationsSemantic proximity Read ↗

The mechanisms of class 1A PI3K and Wnt/β-catenin coupled signaling in breast cancerSemantic proximity Read ↗

PIK3CA mutations in breast cancer are associated with poor outcome.Semantic proximity Read ↗

PIK3CA/AKT1 Mutations in Breast Carcinoma: a Comprehensive Review of Experimental and Clinical StudiesSemantic proximity Read ↗

Mutation of genes of the PI3K/AKT pathway in breast cancer supports their potential importance as biomarker for breast cancer aggressiveness.Semantic proximity Read ↗

Transcriptome- and proteome-oriented identification of dysregulated eIF4G, STAT3, and Hippo pathways altered by PIK3CA H1047R in HER2/ER-positive breast cancer.Semantic proximity Read ↗

Allelic expression imbalance of <i>PIK3CA</i> mutations is frequent in breast cancer and prognostically significantSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.