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Article

Molecular Insights of Pathways Resulting from Two Common PIK3CA Mutations in Breast Cancer.

Cancer research - 1 Jul 2016

Bhat-Nakshatri Poornima, Goswami Chirayu P, Badve Sunil, Magnani Luca, Lupien Mathieu, Nakshatri Harikrishna

Abstract excerpt

The PI3K pathway is activated in approximately 70% of breast cancers. PIK3CA gene mutations or amplifications that affect the PI3K p110α subunit account for activation of this pathway in 20% to 40% of cases, particularly in estrogen receptor alpha (ERα)-positive breast cancers. AKT family of kinases, AKT1-3, are the downstream targets of PI3K and these kinases activate ERα. Although several inhibitors of PI3K...

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Share to Class I Phosphatidylinositol 3-Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Phosphatidylinositol 3-Kinases

Share to Proto-Oncogene Proteins c-akt

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Identifiers

PMID: 27197157
DOI: 10.1158/0008-5472.CAN-15-3174

Genes

AKT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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