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Article

The mechanisms of class 1A PI3K and Wnt/β-catenin coupled signaling in breast cancer

20 Jul 2023

Abstract excerpt

The class IA PI3K signaling pathway is activated by growth factor stimulation and regulates a signaling cascade that promotes diverse events including cell growth, proliferation, migration and metabolism. PI3K signaling is one of the most commonly hyperactivated pathways in breast cancer, leading to increased tumor growth and progression. PI3K hyperactivation occurs via a number of genetic and epigenetic...

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PMID: 37471270
DOI: 10.1042/bst20220866

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