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Article

LRG1 mRNA expression in breast cancer associates with PIK3CA genotype and with aromatase inhibitor therapy outcome.

Molecular oncology - 1 Oct 2016

Ramirez-Ardila Diana E, Ruigrok-Ritstier Kirsten, Helmijr Jean C, Look Maxime P, van Laere Steven, Dirix Luc, Berns Els M J J, Jansen Maurice P H M

Abstract excerpt

BACKGROUND: PIK3CA is the most frequent somatic mutated oncogene in estrogen receptor (ER) positive breast cancer. We previously observed an association between PIK3CA genotype and aromatase inhibitors (AI) treatment outcome. This study now evaluates whether expression of mRNAs and miRs are linked to PIK3CA genotype and are independently related to AI therapy response in order to define potential expressed...

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Share to Aromatase Inhibitors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Class I Phosphatidylinositol 3-Kinases

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Share to Gene Expression Regulation, Neoplastic

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Source

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Identifiers

PMID: 27491861
DOI: 10.1016/j.molonc.2016.07.004
PMCID: PMC5423197

Genes

LRG1
PLCL1
PGR
SERPINA3
CCNO
NEK10
SORBS2
VTCN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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