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The Effect and Treatment of PIK3CA Mutations in Breast Cancer: Current Understanding and Future Directions

17 Mar 2025

Abstract excerpt

Gene mutations in PIK3CA, the catalytic subunit of phosphoinositide 3-kinases, are significantly associated with prognosis in breast cancer. This association suggests that breast cancer patients with PIK3CA mutations should receive PIK3CA mutant-specific treatment. This review aimed to investigate novel treatments for PIK3CA-mutant breast cancer. This study investigated the effects of PIK3CA mutations in breast...

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PMID: 40142329
DOI: 10.3390/medicina61030518

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