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Article

Compensatory Evolution of Net-Charge in Influenza A Virus Hemagglutinin

12 Jul 2012

Abstract excerpt

The propagation of influenza A virus depends on the balance between the activities of hemagglutinin (HA) for binding to host cells and neuraminidase (NA) for releasing from infected cells (HA-NA balance). Since the host cell membrane and the sialic acid receptor are negatively charged, the amino acid substitutions increasing (charge+) and decreasing (charge-) the positive charge of HA subunit 1 (HA1) enhance and...

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PMID: 22808159
DOI: 10.1371/journal.pone.0040422

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