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Article

Transcriptional suppression of connexin43 by TBX18 undermines cell-cell electrical coupling in postnatal cardiomyocytes.

The Journal of biological chemistry - 22 Apr 2011

Kapoor Nidhi, Galang Giselle, Marbán Eduardo, Cho Hee Cheol

Abstract excerpt

T-box transcription factors figure prominently in embryonic cardiac cell lineage specifications. Mesenchymal precursor cells expressing Tbx18 give rise to the heart's pacemaker, the sinoatrial node (SAN). We sought to identify targets of TBX18 transcriptional regulation in the heart by forced adenoviral overexpression in postnatal cardiomyocytes. Neonatal rat cardiomyocytes (NRCMs) transduced with GFP showed...

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Source

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Identifiers

PMID: 21205823
DOI: 10.1074/jbc.M110.185298
PMCID: PMC3077608

Genes

TBX18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Transcriptional suppression of connexin43 by TBX18 undermines cell-cell electrical coupling in postnatal cardiomyocytes.PMID 21205823Read ↗

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Transcription Factor Tbx3 Is Required for the Specification of the Atrioventricular Conduction SystemSemantic proximity Read ↗

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T‐box transcription factor Tbx2 represses differentiation and formation of the cardiac chambersSemantic proximity Read ↗

Transcriptome analysis of mouse and human sinoatrial node cells reveals a conserved genetic programSemantic proximity Read ↗

Tbx18 promoted the conversion of human‐induced pluripotent stem cell‐derived cardiomyocytes into sinoatrial node‐like pacemaker cellsSemantic proximity Read ↗

Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formationSemantic proximity Read ↗

Inhibition of Tgfβ signaling enables durable ventricular pacing by TBX18 gene transferSemantic proximity Read ↗

Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development.Semantic proximity Read ↗

Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43.Semantic proximity Read ↗

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