Article
Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43.
Circulation research - 16 Feb 2001
Gutstein D E, Morley G E, Tamaddon H, Vaidya D, Schneider M D, Chen J, Chien K R, Stuhlmann H, Fishman G I
Abstract excerpt
Cardiac arrhythmia is a common and often lethal manifestation of many forms of heart disease. Gap junction remodeling has been postulated to contribute to the increased propensity for arrhythmogenesis in diseased myocardium, although a causative role in vivo remains speculative. By generating mice with cardiac-restricted knockout of connexin43 (Cx43), we have circumvented the perinatal lethal developmental defect...
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