Article
TBX18 transcription factor overexpression in human-induced pluripotent stem cells increases their differentiation into pacemaker-like cells.
Journal of cellular physiology - 1 Feb 2019
Gorabi Armita M, Hajighasemi Saeideh, Tafti Hossein A, Atashi Amir, Soleimani Masoud, Aghdami Nasser, Saeid Ali K, Khori Vahid, Panahi Yunes, Sahebkar Amirhossein
Abstract excerpt
BACKGROUND: The discovery of gene- and cell-based strategies has opened a new area to investigate novel approaches for the treatment of many conditions caused by cardiac cell failure. The TBX18 (T-box 18) transcription factor is considered as a prominent factor in the sinoatrial node (SAN) formation during the embryonic development. In this in vitro study, the effect of TBX18 gene expression on human-induced...
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