Article
Glycosylation-independent binding to extracellular domains 11-13 of mannose-6-phosphate/insulin-like growth factor-2 receptor mediates the effects of soluble CREG on the phenotypic modulation of vascular smooth muscle cells.
Journal of molecular and cellular cardiology - 1 Apr 2011
Han Yaling, Luan Bo, Sun Mingyu, Guo Liang, Guo Peng, Tao Jie, Deng Jie, Wu Guangzhe, Liu Shaowei, Yan Chenghui, Li Shaohua
Abstract excerpt
The bio-effects of cellular repressor of E1A-stimulated genes (CREG) have been proposed to depend on its N-glycosylation and binding to mannose-6-phosphate/insulin-like growth factor-2 receptor (M6P/IGF2R). The present study aimed to investigate the detailed mode and specific sites for their bind...
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