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Article

IGF1 Binding to Integrin αvβ3 Induces Direct Gα13 Binding to IGF1R Kinase.

International journal of molecular sciences - 30 Apr 2026

Takada Yoko K, Wu Chun-Yi, Takada Yoshikazu

Abstract excerpt

IGF1 plays a critical role in cell proliferation and survival. Previous studies show that IGF1 binds to integrin αvβ3 and induces αvβ3-IGF1-IGF1R ternary complex formation. However, how IGF1 binding to αvβ3 leads to IGF1R activation is unclear. Previous studies showed that Gα13, a guanine nucleotide-binding protein of the G12 class of Gα proteins, binds to the integrin β3 tail through the EEE motif upon...

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Share to Binding Sites
Share to Cell Survival
Share to GTP-Binding Protein alpha Subunits, G12-G13

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin-Like Growth Factor I

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Share to Molecular Docking Simulation

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Share to Receptor, IGF Type 1

Source

Open in PubMed Open full text

Identifiers

PMID: 42123623
DOI: 10.3390/ijms27094042
PMCID: PMC13164005

Genes

IGF1R
IGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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